open_targets.target_safety_event

Python

In [1]:

import bedrock_bio as bb

rel = bb.load_table('open_targets.target_safety_event')

df = rel.limit(5).pl()  # Polars
df = rel.limit(5).df()  # Pandas
df.head()

Out[1]:

	targetId	event	eventId	effects	biosamples	datasource	literature	url	studies	version
0	ENSG00000085563	regulation of transcription factor activity	None	<NA>	[{'tissueLabel': None, 'tissueId': None, 'cell...	ToxCast	None	https://www.epa.gov/chemical-research/explorin...	[{'description': 'LTEA_HepaRG_ABCB1is one of 1...	26.09
1	ENSG00000073734	regulation of transcription factor activity	None	<NA>	[{'tissueLabel': None, 'tissueId': None, 'cell...	ToxCast	None	https://www.epa.gov/chemical-research/explorin...	[{'description': 'LTEA_HepaRG_ABCB11is one of ...	26.09
2	ENSG00000023839	regulation of transcription factor activity	None	<NA>	[{'tissueLabel': None, 'tissueId': None, 'cell...	ToxCast	None	https://www.epa.gov/chemical-research/explorin...	[{'description': 'LTEA_HepaRG_ABCC2is one of 1...	26.09
3	ENSG00000108846	regulation of transcription factor activity	None	<NA>	[{'tissueLabel': None, 'tissueId': None, 'cell...	ToxCast	None	https://www.epa.gov/chemical-research/explorin...	[{'description': 'LTEA_HepaRG_ABCC3is one of 1...	26.09
4	ENSG00000118777	regulation of transcription factor activity	None	<NA>	[{'tissueLabel': None, 'tissueId': None, 'cell...	ToxCast	None	https://www.epa.gov/chemical-research/explorin...	[{'description': 'LTEA_HepaRG_ABCG2is one of 1...	26.09

R

In [1]:

library(bedrockbio)

lf <- load_table("open_targets.target_safety_event")
df <- head(lf, 5) |> collect()

head(df)

Out[1]:

Sample output (5 rows, showing 7 of 10 columns)
   targetId        | event                    | eventId | datasource | literature | url                      | version
   --------------- | ------------------------ | ------- | ---------- | ---------- | ------------------------ | -------
0  ENSG00000085563 | regulation of transcrip… | —       | ToxCast    | —          | https://www.epa.gov/che… | 26.09
1  ENSG00000073734 | regulation of transcrip… | —       | ToxCast    | —          | https://www.epa.gov/che… | 26.09
2  ENSG00000023839 | regulation of transcrip… | —       | ToxCast    | —          | https://www.epa.gov/che… | 26.09
3  ENSG00000108846 | regulation of transcrip… | —       | ToxCast    | —          | https://www.epa.gov/che… | 26.09
4  ENSG00000118777 | regulation of transcrip… | —       | ToxCast    | —          | https://www.epa.gov/che… | 26.09

Description

Safety-related events associated with biological targets, including assay observations, affected biosamples, supporting studies, and evidence sources [Target]

Partitions

Not partitioned.

Schema

Column	Type	Description
targetId	TEXT	Ensembl gene identifier of the target the safety event was reported on [bioregistry:ensembl]
event	TEXT	Safety event associated with the target
eventId	TEXT	Unique identifier for the safety event
effects	STRUCT(direction TEXT, dosing TEXT)[]	Effects reported for the safety event
biosamples	STRUCT(tissueLabel TEXT, tissueId TEXT, cellLabel TEXT, cellFormat TEXT, cellId TEXT)[]	Biosamples used in safety assessments
datasource	TEXT	Data source reporting the safety event
literature	TEXT	Literature references for the safety event
url	TEXT	URL linking to more details on the safety event
studies	STRUCT(description TEXT, name TEXT, type TEXT)[]	Studies related to safety assessments
version	TEXT	Open Targets Platform release version (major.minor), e.g. 26.09. Added during ingest.