evidence_impc

Identifier

open_targets.evidence_impc

Description

Disease-target evidence based on mouse knock-out models, where mouse phenotypes are mapped to human diseases by PhenoDigm algorithm.

Data provided by IMPC [Target-Disease]

Partitions

• release
  • '26.06'

Schema

Column	Type	Description
targetId	TEXT	Open Targets target identifier
id	TEXT	Identifer of the disease/target evidence
targetFromSourceId	TEXT	Target ID in resource of origin (accepted sources include Ensembl gene ID, Uniprot ID, gene symbol), only capital letters are accepted
diseaseFromSourceMappedId	TEXT	Mapped Open Targets disease identifier
targetInModelMgiId	TEXT	Target MGI ID in animal model [bioregistry:mgi]
diseaseFromSourceId	TEXT	Disease identifier from the original source
biologicalModelGeneticBackground	TEXT	Genetic background of the model organism
biologicalModelAllelicComposition	TEXT	Allelic composition of the model organism
diseaseFromSource	TEXT	Disease label from the original source
resourceScore	DOUBLE	Score provided by datasource indicating strength of target-disease association
targetInModel	TEXT	Target name/synonym in animal model
targetInModelEnsemblId	TEXT	Target Ensembl ID in animal model [bioregistry:ensembl]
diseaseModelAssociatedModelPhenotypes	STRUCT(id TEXT, label TEXT)[]	Phenotypes observed in genetically modified animal models
diseaseModelAssociatedHumanPhenotypes	STRUCT(id TEXT, label TEXT)[]	Human phenotypes equivalent to those observed in animal models
literature	TEXT[]	List of PubMed or preprint reference identifiers
biologicalModelId	TEXT	Identifier of the biological model (eg. in MGI)
datasourceId	TEXT	Identifer of the evidence source
datatypeId	TEXT	Type of the evidence
qualityControls	TEXT[]	Evidence quality flags
diseaseId	TEXT	Open Targets disease identifier
publicationDate	TEXT	Date of the earliest publication supporting the evidence
evidenceDate	TEXT	Earliest data for the evidence
score	DOUBLE	Score of the evidence reflecting the strength of the disease/target relationship
directionOnTrait	TEXT	Predicted direction of effect on the trait
directionOnTarget	TEXT	Gain or loss of function effect of the evidence on the target resulting from genetic variants, pharmacological modulation, or other perturbations
release	TEXT	Partition column. Open Targets Platform release version (major.minor), e.g. 26.06. [Added during ingest.]