open_targets.homology

Python

In [1]:

import bedrock_bio as bb

rel = bb.load_table('open_targets.homology')

df = rel.limit(5).pl()  # Polars
df = rel.limit(5).df()  # Pandas
df.head()

Out[1]:

	targetId	speciesId	speciesName	homologyType	targetGeneId	isHighConfidence	targetGeneSymbol	queryPercentageIdentity	targetPercentageIdentity	priority	version
0	ENSG00000231192	9606	Human	other_paralog	ENSG00000279395	None	OR5L1	41.5335	41.8006	0	26.09
1	ENSG00000231192	9606	Human	other_paralog	ENSG00000205030	None	OR5L2	41.8530	42.1222	0	26.09
2	ENSG00000231192	9606	Human	other_paralog	ENSG00000186119	None	OR5D18	42.8115	42.8115	0	26.09
3	ENSG00000231192	9606	Human	other_paralog	ENSG00000205029	None	OR5D16	38.9776	37.1951	0	26.09
4	ENSG00000231192	9606	Human	other_paralog	ENSG00000279761	None	OR5D13	40.5751	40.4459	0	26.09

R

In [1]:

library(bedrockbio)

lf <- load_table("open_targets.homology")
df <- head(lf, 5) |> collect()

head(df)

Out[1]:

Sample output (5 rows, showing 8 of 11 columns)
   targetId        | speciesId | speciesName | homologyType  | targetGeneId    | isHighConfidence | targetGeneSymbol | queryPercentageIdentity
   --------------- | --------- | ----------- | ------------- | --------------- | ---------------- | ---------------- | -----------------------
0  ENSG00000231192 | 9606      | Human       | other_paralog | ENSG00000279395 | —                | OR5L1            | 41.5335
1  ENSG00000231192 | 9606      | Human       | other_paralog | ENSG00000205030 | —                | OR5L2            | 41.853
2  ENSG00000231192 | 9606      | Human       | other_paralog | ENSG00000186119 | —                | OR5D18           | 42.8115
3  ENSG00000231192 | 9606      | Human       | other_paralog | ENSG00000205029 | —                | OR5D16           | 38.9776
4  ENSG00000231192 | 9606      | Human       | other_paralog | ENSG00000279761 | —                | OR5D13           | 40.5751

Description

Ensembl compara homologue/ortholog pairs for each target, resolved to Ensembl target identifiers [Target]

Partitions

Not partitioned.

Schema

Column	Type	Description
targetId	TEXT	Ensembl gene identifier of the query target [bioregistry:ensembl]
speciesId	TEXT	Species ID for the homologue
speciesName	TEXT	Species name for the homologue
homologyType	TEXT	Type of homology relationship
targetGeneId	TEXT	Target gene ID of the homologue
isHighConfidence	TEXT	Indicates if the homology is high confidence
targetGeneSymbol	TEXT	Gene symbol of the homologous target
queryPercentageIdentity	DOUBLE	Percentage identity of the query gene in the homologue
targetPercentageIdentity	DOUBLE	Percentage identity of the homologue in the query gene
priority	INT	Priority score for the homologue
version	TEXT	Open Targets Platform release version (major.minor), e.g. 26.09. Added during ingest.