target

Identifier

open_targets.target

Description

Core annotation for drug targets (gene/proteins).

Targets are defined based on EMBL-EBI Ensembl database and uses the Ensembl gene ID as the primary identifier.

An Ensembl gene ID is considered potential drug target if included in the canonical assembly or if present alternative assemblies but encoding for a reviewed protein product according to the UniProt database [Target]

Partitions

• release
  • '26.06'

Schema

Column	Type	Description
id	TEXT	Unique identifier for the target [bioregistry:ensembl]
approvedSymbol	TEXT	Approved gene symbol of the target
biotype	TEXT	Biotype classification of the target gene, indicating if the gene is protein coding
alternativeGenes	TEXT[]	List of alternative Ensembl gene identifiers mapped to non-canonical chromosomes
genomicLocation	STRUCT(chromosome TEXT, start BIGINT, end BIGINT, strand INT)	Genomic location information of the target gene
transcriptIds	TEXT[]	List of Ensembl transcript identifiers associated with the target
canonicalExons	TEXT[]	List of canonical exons for the target gene
transcripts	STRUCT(transcriptId TEXT, biotype TEXT, uniprotId TEXT, isUniprotReviewed BOOLEAN, translationId TEXT, alphafoldId TEXT, uniprotIsoformId TEXT, isEnsemblCanonical BOOLEAN)[]	List of transcripts of the target Extracted from Ensembl
canonicalTranscript	STRUCT(id TEXT, chromosome TEXT, start BIGINT, end BIGINT, strand TEXT)	The Ensembl canonical transcript of the target gene
approvedName	TEXT	Approved full name of the target gene
go	STRUCT(id TEXT, source TEXT, evidence TEXT, aspect TEXT, geneProduct TEXT, ecoId TEXT)[]	List of Gene Ontology (GO) annotations related to the target
hallmarks	STRUCT(attributes STRUCT(pmid BIGINT, description TEXT, name TEXT)[], cancerHallmarks STRUCT(pmid BIGINT, description TEXT, impact TEXT, label TEXT)[])	Hallmarks related to the target gene sourced from COSMIC
synonyms	STRUCT(label TEXT, source TEXT)[]	List of synonyms for the target gene
symbolSynonyms	STRUCT(label TEXT, source TEXT)[]	List of symbol-based synonyms for the target gene
nameSynonyms	STRUCT(label TEXT, source TEXT)[]	List of name-based synonyms for the target gene
functionDescriptions	TEXT[]	Functional descriptions of the target gene sourced from UniProt
subcellularLocations	STRUCT(location TEXT, source TEXT, termSL TEXT, labelSL TEXT, targetModifier TEXT)[]	List of subcellular locations where the target protein is found
targetClass	STRUCT(id BIGINT, label TEXT, level TEXT)[]	Target classification categories from ChEMBL
obsoleteSymbols	STRUCT(label TEXT, source TEXT)[]	List of obsolete symbols previously used for the target gene
obsoleteNames	STRUCT(label TEXT, source TEXT)[]	List of obsolete names previously used for the target gene
constraint	STRUCT(constraintType TEXT, score FLOAT, exp FLOAT, obs INT, oe FLOAT, oeLower FLOAT, oeUpper FLOAT, upperRank INT, upperBin INT, upperBin6 INT)[]	Constraint scores for the target gene from gnomAD
tep	STRUCT(targetFromSourceId TEXT, description TEXT, therapeuticArea TEXT, url TEXT)	Target Enabling Package (TEP) information
proteinIds	STRUCT(id TEXT, source TEXT)[]	Protein identifiers associated with the target
dbXrefs	STRUCT(id TEXT, source TEXT)[]	Database cross-references for the target
chemicalProbes	STRUCT(targetFromSourceId TEXT, id TEXT, drugFromSourceId TEXT, drugId TEXT, mechanismOfAction TEXT[], origin TEXT[], control TEXT, isHighQuality BOOLEAN, probesDrugsScore DOUBLE, probeMinerScore DOUBLE, scoreInCells DOUBLE, scoreInOrganisms DOUBLE, urls STRUCT(niceName TEXT, url TEXT)[])[]	Chemical probes related to the target
homologues	STRUCT(speciesId TEXT, speciesName TEXT, homologyType TEXT, targetGeneId TEXT, isHighConfidence TEXT, targetGeneSymbol TEXT, queryPercentageIdentity DOUBLE, targetPercentageIdentity DOUBLE, priority INT)[]	Homologues of the target gene in other species
tractability	STRUCT(modality TEXT, id TEXT, value BOOLEAN)[]	Tractability information for the target
safetyLiabilities	STRUCT(event TEXT, eventId TEXT, effects STRUCT(direction TEXT, dosing TEXT)[], biosamples STRUCT(tissueLabel TEXT, tissueId TEXT, cellLabel TEXT, cellFormat TEXT, cellId TEXT)[], datasource TEXT, literature TEXT, url TEXT, studies STRUCT(description TEXT, name TEXT, type TEXT)[])[]	Safety liabilities associated with the target
pathways	STRUCT(pathwayId TEXT, pathway TEXT, topLevelTerm TEXT)[]	Pathway annotations for the target
tss	BIGINT	Transcription Start Site (TSS) information for the target
release	TEXT	Partition column. Open Targets Platform release version (major.minor), e.g. 26.06. [Added during ingest.]