evidence_crispr_screen

Identifier

open_targets.evidence_crispr_screen

Description

Disease-target evidence derived from systematic gene perturation assays of CRISPR knock-out screens [Target-Disease]

Partitions

• release
  • '26.06'

Schema

Column	Type	Description
id	TEXT	Identifer of the disease/target evidence
targetFromSourceId	TEXT	Target ID in resource of origin (accepted sources include Ensembl gene ID, Uniprot ID, gene symbol), only capital letters are accepted
diseaseFromSourceMappedId	TEXT	Mapped Open Targets disease identifier
studyId	TEXT	Identifier of the study generating the data
datatypeId	TEXT	Type of the evidence
datasourceId	TEXT	Identifer of the evidence source
projectId	TEXT	The identifer of the project that generated the data
crisprScreenLibrary	TEXT	Applied screening library in the CRISPR/Cas9 project
studyOverview	TEXT	Description of the study
cellType	TEXT	The studied cell type. Preferably the cell line ontology label
geneticBackground	TEXT	Additional genetic background of the applied cell line in the CRISPR screen
literature	TEXT[]	List of PubMed or preprint reference identifiers
diseaseFromSource	TEXT	Disease label from the original source
contrast	TEXT	Experiment contrast
resourceScore	DOUBLE	Score provided by datasource indicating strength of target-disease association
statisticalTestTail	TEXT	End of the distribution the target was picked from
log2FoldChangeValue	DOUBLE	Log 2 fold expression change in contrast experiment
qualityControls	TEXT[]	Evidence quality flags
diseaseId	TEXT	Open Targets disease identifier
targetId	TEXT	Open Targets target identifier
publicationDate	TEXT	Date of the earliest publication supporting the evidence
evidenceDate	TEXT	Earliest data for the evidence
score	DOUBLE	Score of the evidence reflecting the strength of the disease/target relationship
release	TEXT	Partition column. Open Targets Platform release version (major.minor), e.g. 26.06. [Added during ingest.]