target_prioritisation

Identifier

open_targets.target_prioritisation

Description

List of target-specific attributes from the Target Engine project [Target]

Partitions

• release
  • '26.06'

Schema

Column	Type	Description
targetId	TEXT	Unique identifier for the target, typically an Ensembl gene ID
isInMembrane	INT	Indicates if the target protein is located in the cell or plasma membrane
isSecreted	INT	Indicates if the target protein is secreted or predicted to be secreted
hasSafetyEvent	INT	Indicates if there are known safety events associated with the target
hasPocket	INT	Indicates if the target has predicted binding pockets suitable for small molecule binding
hasLigand	INT	Indicates if the target binds at least one high-quality ligand
hasSmallMoleculeBinder	INT	Indicates if the target has at least one small molecule binder
geneticConstraint	DOUBLE	Represents the genetic constraint of the target, indicating how intolerant it is to genetic variation
paralogMaxIdentityPercentage	DOUBLE	Maximum percentage identity among the target’s paralogues
mouseOrthologMaxIdentityPercentage	DOUBLE	Maximum percentage identity between the target and its mouse ortholog
isCancerDriverGene	INT	Indicates if the target is identified as a cancer driver gene
hasTEP	INT	Indicates if a Target Enabling Package (TEP) is available for the target
mouseKOScore	DOUBLE	Represents the phenotypic score from mouse knockout models for the target
hasHighQualityChemicalProbes	INT	Indicates if there are high-quality chemical probes available for the target
maxClinicalStage	DOUBLE	Score derived from the highest clinical stage that the target has reached for any indication
tissueSpecificity	DOUBLE	Describes the specificity of the target’s expression across different tissues
tissueDistribution	DOUBLE	Describes the distribution pattern of the target’s expression in various tissues
celltypeSpecificity	DOUBLE	Describes the specificity of the target’s expression across different cell types
celltypeDistribution	DOUBLE	Describes the distribution pattern of the target’s expression in various cell types
release	TEXT	Partition column. Open Targets Platform release version (major.minor), e.g. 26.06. [Added during ingest.]