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bedrock.bio

open_targets.target_prioritisation

import bedrock_bio as bb

rel = bb.load_table('open_targets.target_prioritisation')

df = rel.limit(5).pl()  # Polars
df = rel.limit(5).df()  # Pandas
df.head()
targetId isInMembrane isSecreted hasSafetyEvent hasPocket hasLigand hasSmallMoleculeBinder geneticConstraint paralogMaxIdentityPercentage mouseOrthologMaxIdentityPercentage isCancerDriverGene mouseKOScore hasHighQualityChemicalProbes maxClinicalStage tissueSpecificity tissueDistribution celltypeSpecificity celltypeDistribution version
0 ENSG00000083454 1 0 -1 0 0 1 0.328294 0.0 0.000000 <NA> NaN <NA> NaN 0.323480 0.185185 0.639241 0.747059 26.09
1 ENSG00000087087 0 0 <NA> 0 0 0 -0.735963 NaN 0.880135 <NA> NaN <NA> NaN -0.548996 -1.000000 -0.611189 0.023529 26.09
2 ENSG00000092201 0 0 <NA> 0 0 0 -0.913667 NaN 0.937920 <NA> -0.684599 <NA> NaN -0.551439 -1.000000 -0.621974 0.005882 26.09
3 ENSG00000100567 0 0 <NA> 0 1 1 -0.798740 0.0 0.941175 <NA> NaN <NA> 1.0 -0.535522 -1.000000 -0.297486 -1.000000 26.09
4 ENSG00000105707 1 0 <NA> 0 1 1 -0.789428 0.0 0.388490 <NA> -0.303437 <NA> NaN 0.577974 0.074074 0.257584 0.476471 26.09

Description

Section titled “Description”

List of target-specific attributes from the Target Engine project [Target]

Partitions

Section titled “Partitions”

Not partitioned.

Schema

Section titled “Schema”
Column Type Description
targetId TEXT Unique identifier for the target, typically an Ensembl gene ID
isInMembrane INT Indicates if the target protein is located in the cell or plasma membrane
isSecreted INT Indicates if the target protein is secreted or predicted to be secreted
hasSafetyEvent INT Indicates if there are known safety events associated with the target
hasPocket INT Indicates if the target has predicted binding pockets suitable for small molecule binding
hasLigand INT Indicates if the target binds at least one high-quality ligand
hasSmallMoleculeBinder INT Indicates if the target has at least one small molecule binder
geneticConstraint DOUBLE Represents the genetic constraint of the target, indicating how intolerant it is to genetic variation
paralogMaxIdentityPercentage DOUBLE Maximum percentage identity among the target’s paralogues
mouseOrthologMaxIdentityPercentage DOUBLE Maximum percentage identity between the target and its mouse ortholog
isCancerDriverGene INT Indicates if the target is identified as a cancer driver gene
mouseKOScore DOUBLE Represents the phenotypic score from mouse knockout models for the target
hasHighQualityChemicalProbes INT Indicates if there are high-quality chemical probes available for the target
maxClinicalStage DOUBLE Score derived from the highest clinical stage that the target has reached for any indication
tissueSpecificity DOUBLE Describes the specificity of the target’s expression across different tissues
tissueDistribution DOUBLE Describes the distribution pattern of the target’s expression in various tissues
celltypeSpecificity DOUBLE Describes the specificity of the target’s expression across different cell types
celltypeDistribution DOUBLE Describes the distribution pattern of the target’s expression in various cell types
version TEXT Open Targets Platform release version (major.minor), e.g. 26.09. Added during ingest.