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bedrock.bio

evidence_gene_burden

Identifier

Section titled “Identifier”
open_targets.evidence_gene_burden

Description

Section titled “Description”

Disease-target evidence based on testing aggregated effect of variants, curated from the literature by the Open Targets team [Target-Disease]

Partitions

Section titled “Partitions”
  • release
    • '26.06'

Schema

Section titled “Schema”
Column Type Description
targetId TEXT Open Targets target identifier
id TEXT Identifer of the disease/target evidence
targetFromSourceId TEXT Target ID in resource of origin (accepted sources include Ensembl gene ID, Uniprot ID, gene symbol), only capital letters are accepted
diseaseFromSourceMappedId TEXT Mapped Open Targets disease identifier
datasourceId TEXT Identifer of the evidence source
datatypeId TEXT Type of the evidence
allelicRequirements TEXT[] Inheritance patterns
diseaseFromSource TEXT Disease label from the original source
pValueMantissa DOUBLE Mantissa of the p-value
pValueExponent BIGINT Exponent of the p-value
beta DOUBLE Effect size of numeric traits
betaConfidenceIntervalLower DOUBLE Lower value of the confidence interval
betaConfidenceIntervalUpper DOUBLE Upper value of the confidence interval
oddsRatio DOUBLE Size of effect captured as odds ratio
oddsRatioConfidenceIntervalLower DOUBLE Lower value of the confidence interval for odds ratio
oddsRatioConfidenceIntervalUpper DOUBLE Upper value of the confidence interval for odds ratio
resourceScore DOUBLE Score provided by datasource indicating strength of target-disease association
ancestry TEXT Genetic origin of a population
ancestryId TEXT Identifier of the ancestry in the HANCESTRO ontology [bioregistry:hancestro]
literature TEXT[] List of PubMed or preprint reference identifiers
projectId TEXT The identifer of the project that generated the data
cohortId TEXT Identifier of the studied cohort
releaseVersion TEXT Open Targets data release version
studySampleSize BIGINT Sample size of study
studyCases BIGINT Number of cases in case-control study
studyCasesWithQualifyingVariants BIGINT Number of cases in case-control study that carry at least one allele of the qualifying variant
statisticalMethod TEXT Statistical method used to calculate the association
statisticalMethodOverview TEXT Overview of the statistical method used to calculate the association
urls STRUCT(niceName TEXT, url TEXT)[] Reference to linked external resource (e.g. clinical trials, studies, package inserts, reports, etc.)
sex TEXT[] Sex of the samples/population included in the analysis
diseaseFromSourceId TEXT Disease identifier from the original source
qualityControls TEXT[] Evidence quality flags
diseaseId TEXT Open Targets disease identifier
publicationDate TEXT Date of the earliest publication supporting the evidence
evidenceDate TEXT Earliest data for the evidence
score DOUBLE Score of the evidence reflecting the strength of the disease/target relationship
directionOnTrait TEXT Predicted direction of effect on the trait
directionOnTarget TEXT Gain or loss of function effect of the evidence on the target resulting from genetic variants, pharmacological modulation, or other perturbations
release TEXT Partition column. Open Targets Platform release version (major.minor), e.g. 26.06. [Added during ingest.]