open_targets.drug_mechanism_of_action

Python

In [1]:

import bedrock_bio as bb

rel = bb.load_table('open_targets.drug_mechanism_of_action')

df = rel.limit(5).pl()  # Polars
df = rel.limit(5).df()  # Pandas
df.head()

Out[1]:

	mechanismOfAction	actionType	chemblIds	references	targetName	targetType	targets	version
0	Carbonic anhydrase VII inhibitor	INHIBITOR	[CHEMBL19]	[{'source': 'PubMed', 'ids': ['18336310', '183...	Carbonic anhydrase 7	single protein	[ENSG00000168748]	26.09
1	Carbonic anhydrase I inhibitor	INHIBITOR	[CHEMBL1201117]	[{'source': 'PubMed', 'ids': ['1460006'], 'url...	Carbonic anhydrase 1	single protein	[ENSG00000133742]	26.09
2	Carbonic anhydrase I inhibitor	INHIBITOR	[CHEMBL1200814, CHEMBL20]	[{'source': 'PubMed', 'ids': ['10713865', '183...	Carbonic anhydrase 1	single protein	[ENSG00000133742]	26.09
3	Carbonic anhydrase I inhibitor	INHIBITOR	[CHEMBL17]	[{'source': 'PubMed', 'ids': ['18336310', '183...	Carbonic anhydrase 1	single protein	[ENSG00000133742]	26.09
4	Carbonic anhydrase I inhibitor	INHIBITOR	[CHEMBL19]	[{'source': 'PubMed', 'ids': ['18336310', '183...	Carbonic anhydrase 1	single protein	[ENSG00000133742]	26.09

R

In [1]:

library(bedrockbio)

lf <- load_table("open_targets.drug_mechanism_of_action")
df <- head(lf, 5) |> collect()

head(df)

Out[1]:

Sample output (5 rows, showing 5 of 8 columns)
   mechanismOfAction        | actionType | targetName           | targetType     | version
   ------------------------ | ---------- | -------------------- | -------------- | -------
0  Carbonic anhydrase VII … | INHIBITOR  | Carbonic anhydrase 7 | single protein | 26.09
1  Carbonic anhydrase I in… | INHIBITOR  | Carbonic anhydrase 1 | single protein | 26.09
2  Carbonic anhydrase I in… | INHIBITOR  | Carbonic anhydrase 1 | single protein | 26.09
3  Carbonic anhydrase I in… | INHIBITOR  | Carbonic anhydrase 1 | single protein | 26.09
4  Carbonic anhydrase I in… | INHIBITOR  | Carbonic anhydrase 1 | single protein | 26.09

Description

Mechanisms of action for drug or clinical candidate molecules included in ChEMBL database.

The mechanism of action includes information about the pharmacological target of the drug, the mode of action and the drug modality [Drug]

Partitions

Not partitioned.

Schema

Column	Type	Description
mechanismOfAction	TEXT	Drug pharmacological action
actionType	TEXT	Classification of how the drug interacts with its target (e.g., ACTIVATOR)
chemblIds	TEXT[]	List of Open Targets molecule identifiers
references	STRUCT(source TEXT, ids TEXT[], urls TEXT[])[]	List of sources documenting the mechanism information
targetName	TEXT	Specific biological entity on which the drug has an effect
targetType	TEXT	Classification of the target’s biological category (e.g., protein complex)
targets	TEXT[]	List of Open Targets target identifiers
version	TEXT	Open Targets Platform release version (major.minor), e.g. 26.09. Added during ingest.