open_targets.interaction

Python

In [1]:

import bedrock_bio as bb

rel = bb.load_table('open_targets.interaction')

df = rel.limit(5).pl()  # Polars
df = rel.limit(5).df()  # Pandas
df.head()

Out[1]:

	sourceDatabase	targetA	intA	intABiologicalRole	targetB	intB	intBBiologicalRole	speciesA	speciesB	count	scoring	interactionId	version
0	string	ENSG00000093072	ENSP00000382731	unspecified role	ENSG00000129744	ENSP00000250693	unspecified role	{'mnemonic': 'human', 'scientificName': 'Homo ...	{'mnemonic': 'human', 'scientificName': 'Homo ...	1	0.169	6950511739585731406	26.09
1	string	ENSG00000162630	ENSP00000356404	unspecified role	ENSG00000070731	ENSP00000225276	unspecified role	{'mnemonic': 'human', 'scientificName': 'Homo ...	{'mnemonic': 'human', 'scientificName': 'Homo ...	1	0.275	-2461805918294658959	26.09
2	string	ENSG00000169018	ENSP00000307298	unspecified role	ENSG00000091490	ENSP00000382767	unspecified role	{'mnemonic': 'human', 'scientificName': 'Homo ...	{'mnemonic': 'human', 'scientificName': 'Homo ...	2	0.191	6115706461929273405	26.09
3	string	ENSG00000277586	ENSP00000482169	unspecified role	ENSG00000135406	ENSP00000257860	unspecified role	{'mnemonic': 'human', 'scientificName': 'Homo ...	{'mnemonic': 'human', 'scientificName': 'Homo ...	4	0.902	-3346729623609111558	26.09
4	string	ENSG00000185049	ENSP00000445757	unspecified role	ENSG00000169375	ENSP00000378402	unspecified role	{'mnemonic': 'human', 'scientificName': 'Homo ...	{'mnemonic': 'human', 'scientificName': 'Homo ...	1	0.337	-2799363509010290707	26.09

R

In [1]:

library(bedrockbio)

lf <- load_table("open_targets.interaction")
df <- head(lf, 5) |> collect()

head(df)

Out[1]:

Sample output (5 rows, showing 8 of 13 columns)
   sourceDatabase | targetA         | intA            | intABiologicalRole | targetB         | intB            | intBBiologicalRole | count
   -------------- | --------------- | --------------- | ------------------ | --------------- | --------------- | ------------------ | -----
0  string         | ENSG00000093072 | ENSP00000382731 | unspecified role   | ENSG00000129744 | ENSP00000250693 | unspecified role   | 1
1  string         | ENSG00000162630 | ENSP00000356404 | unspecified role   | ENSG00000070731 | ENSP00000225276 | unspecified role   | 1
2  string         | ENSG00000169018 | ENSP00000307298 | unspecified role   | ENSG00000091490 | ENSP00000382767 | unspecified role   | 2
3  string         | ENSG00000277586 | ENSP00000482169 | unspecified role   | ENSG00000135406 | ENSP00000257860 | unspecified role   | 4
4  string         | ENSG00000185049 | ENSP00000445757 | unspecified role   | ENSG00000169375 | ENSP00000378402 | unspecified role   | 1

Description

Integration of molecular interactions reporting experimental or functional interactions between molecules represented as Platform targets.

This dataset contains pairwise interactions deposited in several databases capturing: physical interactions (e.g. IntAct), directional interactions (e.g. Signor), pathway relationships (e.g. Reactome) or functional interactions (e.g. STRINGdb) [Target]

Partitions

Not partitioned.

Schema

Column	Type	Description
sourceDatabase	TEXT	Source database reporting the molecular interaction
targetA	TEXT	Open Targets target identifier of the first molecule (target A) in the interaction [bioregistry:ensembl]
intA	TEXT	Identifier for target A in source
intABiologicalRole	TEXT	Biological role of target A in the interaction
targetB	TEXT	Open Targets target identifier of the second molecule (target B) in the interaction [bioregistry:ensembl]
intB	TEXT	Identifier for target B in source
intBBiologicalRole	TEXT	Biological role of target B in the interaction
speciesA	STRUCT(mnemonic TEXT, scientificName TEXT, taxonId BIGINT)	Taxonomic annotation of target A
speciesB	STRUCT(mnemonic TEXT, scientificName TEXT, taxonId BIGINT)	Taxonomic annotation of target B
count	BIGINT	Number of interaction occurrences reported in the source databases
scoring	DOUBLE	Scoring or confidence value assigned to the interaction
interactionId	BIGINT	Unique identifier of the molecular interaction
version	TEXT	Open Targets Platform release version (major.minor), e.g. 26.09. Added during ingest.