pharmacogenomics

Identifier

open_targets.pharmacogenomics

Description

Genetic variants influencing individual drug responses.

Pharmacogenetics data is integrated from sources including ClinPGx [Target, Genetics]

Partitions

• release
  • '26.06'

Schema

Column	Type	Description
datasourceId	TEXT	Identifier for the data provider
datasourceVersion	TEXT	Data provider version number
datatypeId	TEXT	Classification of the type of pharmacogenomic data (e.g. clinical_annotation)
directionality	TEXT	Indicates wether the genetic variant increases or decreases drug response
evidenceLevel	TEXT	Strength of the scientific support for the variant/drug response
genotype	TEXT	Genetic variant configuration
genotypeAnnotationText	TEXT	Explanation of the genotype’s clinical significance
genotypeId	TEXT	Identifier for the specific genetic variant combination (e.g. 1_1500_A_A,T)
haplotypeFromSourceId	TEXT	Haplotype ID in the ClinPGx dataset
haplotypeId	TEXT	Combination of genetic variants that constitute a particular allele of a gene (e.g. CYP2C9*3)
literature	TEXT[]	List of PubMed or preprint reference identifiers
pgxCategory	TEXT	Classification of the drug response type (e.g. Toxicity)
phenotypeFromSourceId	TEXT	Open Targets disease identifier result of mapping phenotypeText
phenotypeText	TEXT	Drug response influenced by the variation
variantAnnotation	STRUCT(baseAlleleOrGenotype TEXT, comparisonAlleleOrGenotype TEXT, directionality TEXT, effect TEXT, effectDescription TEXT, effectType TEXT, entity TEXT, id TEXT, literature TEXT)[]	Metadata on the underlying variation
studyId	TEXT	Clinical Annotation ID in the ClinPGx dataset
targetFromSourceId	TEXT	Open Targets target identifier as provided by the data source
variantFunctionalConsequenceId	TEXT	The sequence ontology identifier of the consequence of the variant based on Ensembl VEP in the context of the transcript [bioregistry:so]
variantRsId	TEXT	Variant reference SNP cluster ID (Rsid)
variantId	TEXT	The unique identifier for the variant following schema: {chromosome}-{position}-{referenceAllele}-{alternateAllele}
isDirectTarget	BOOLEAN	Flag indicating whether the target overlapping the variation is directly targeted by the drug
drugs	STRUCT(drugFromSource TEXT, drugId TEXT)[]	List of drug references
release	TEXT	Partition column. Open Targets Platform release version (major.minor), e.g. 26.06. [Added during ingest.]