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bedrock.bio

open_targets.openfda_significant_adverse_drug_reactions

import bedrock_bio as bb

rel = bb.load_table('open_targets.openfda_significant_adverse_drug_reactions')

df = rel.limit(5).pl()  # Polars
df = rel.limit(5).df()  # Pandas
df.head()
chembl_id event count llr critval meddraCode version
0 CHEMBL1076903 abnormal behaviour 34 29.686953 27.763588 26.09
1 CHEMBL1076903 abnormal dreams 146 442.394199 27.763588 26.09
2 CHEMBL1076903 aggression 82 118.065145 27.763588 26.09
3 CHEMBL1076903 agitation 178 304.070849 27.763588 26.09
4 CHEMBL1076903 alcohol use 17 37.809109 27.763588 26.09

Description

Section titled “Description”

Significant adverse drug reactions (ADRs) associated with drugs.

This dataset is based on the FDA’s Adverse Event Reporting System (FAERS) reporting post-marketing surveillance data and it’s filtered to include only reports submitted by health professionals.

The significance of a given drug-ADR is estimated using a Likelihood Ratio Test (LRT) using all reports associated with the given drug [Drug]

Partitions

Section titled “Partitions”

Not partitioned.

Schema

Section titled “Schema”
Column Type Description
chembl_id TEXT Unique identifier for the drug or clinical candidate
event TEXT Reported adverse drug reaction associated with the drug
count BIGINT Number of occurrences of the adverse event in the dataset
llr DOUBLE Log-likelihood ratio (LLR) measuring the strength of the association between the drug and the adverse event
critval DOUBLE Critical value used to determine statistical significance of the association
meddraCode TEXT Medical Dictionary for Regulatory Activities (MedDRA) code for the adverse drug reaction
version TEXT Open Targets Platform release version (major.minor), e.g. 26.09. Added during ingest.